By | October 15, 2021

The Amyloidosis refers to a pathological accumulation of proteins in the intercellular spaces. Amyloidosis itself is not a disease; rather, it causes various diseases. The amyloidosis can only be detected by means of a cytological examination of a tissue sample. It almost exclusively affects older patients around 65 years of age. Amyloidosis can only be treated to a limited extent and is fatal about 24 months after it occurs.

What is amyloidosis?

According to SPORTINGOLOGY.COM, amyloidosis describes a pathological accumulation of proteins in the intercellular spaces, e.g. of lysozyme.

Amyloidosis is a disorder of protein metabolism. A certain protein (eg immunoglobulin , cystatin or lysozyme) cannot or only insufficiently be broken down in a patient suffering from amyloidosis.

As a result, the protein accumulates in the spaces between the cells of various organs – such as the liver , kidneys or heart – and impairs organ activity. The amyloidosis becomes visible on the basis of various diseases that the patient develops. These include, for example, an abnormally enlarged liver, an inflamed heart muscle, unspecific kidney failure or cancer of the bone marrow ( multiple myeloma ).

Occasionally there is an accumulation of proteins in several organs at the same time, so that several organs become ill or fail (multiple organ failure).


The causes of amyloidosis lie in a disorder of the protein metabolism. Proteins are usually found in dissolved form in blood serum.

If the protein is not dissolved or broken down, the concentration is too high. If it cannot be excreted, the protein accumulates in the spaces between the cells. There it is attacked by enzymes; As a result, long chains of amino acids are created, which are visible as small fibers under the microscope.

The fibers cannot be broken down and broken down. As a result, the organ is destroyed to the point of complete inoperability. So far it has not been possible to determine which patients tend to develop amyloidosis; According to the current state of research, a genetic predisposition is assumed.

Symptoms, ailments & signs

In the worst case, amyloidosis can lead to death. The complaints are also relatively serious and should therefore be treated at an early stage. As a rule, the patients suffer from severe cardiac insufficiency . This leads to permanent tiredness and fatigue.

The amyloidosis also significantly reduces the patient’s resilience. In the further course the disease leads to disturbances of the heart rhythm, whereby the heartbeat itself can change. Even light activities can appear very strenuous for the patient, so that there can be restrictions in everyday life. As a result of these restrictions, many sufferers also suffer from depression or other psychological disorders.

Amyloidosis can also lead to dementia . In this case, those affected are often dependent on the help of other people in their everyday life and the quality of life decreases significantly. The stiffening of the heart muscles also reduces the life expectancy of the person affected. Amyloidosis also significantly increases the risk of a heart attack or stroke . Pain in the heart can also lead to a panic attack or fear of death.

Diagnosis & course

A diagnosis can only be made by means of a cytological examination. If typical secondary diseases – such as an enlarged liver, cardiac arrhythmia or kidney failure – have occurred, the doctor should consider amyloidosis and carry out an appropriate laboratory examination.

For this purpose, a tissue sample ( biopsy ) is taken from the affected organ and then examined under the microscope. Amyloidosis is visible through the microscopically visible thread-like structures between the cells. The tissue sample is stained with the dye Congo red. A greenish discoloration of the intercellular spaces is visible under polarized light. A scintigraphy can provide information about the spread of amyloidosis . During a scintigraphy, a radioactive substance is given that is able to bind the amyloidosis and make it visible.

Amyloidosis itself goes unnoticed by the patient. With the progression of amyloidosis – the deposits spread relatively quickly – there are clearly visible secondary diseases that severely restrict the quality of life. Depending on the course, there is an organ insufficiency or an organ failure. Amyloidosis is fatal – around 24 months after it first occurs, one or more organs are no longer functional.


Amyloidosis, which occurs rarely, has a massive impact on the body’s protein balance and changes it. As a result of the insoluble deposit, the vessels, nerves and bones are attacked. The antibodies can no longer disintegrate. If the symptom occurs, a systemic variant can lead to chronic inflammatory flare-ups and assume life-threatening proportions.

There is no cure for amyloidosis, but it can be specifically treated. Early diagnosis helps keep the risk of complications low. This largely spares the patient a possible deterioration in the function of organs and nerves. Amyloidosis occurs gradually. If it shows organ-related symptoms, the organ function can already be impaired to such an extent that it has to be transplanted.

Either the screening method or a tissue sample is considered to make the diagnosis effective. This is followed by typing the symptom. Due to the diversity of the disease, this process must be carried out very carefully. Only when the faulty protein has been identified is a comprehensive therapy plan drawn up.

Chemotherapy as part of medication has proven to be a successful treatment method. Under certain circumstances, the patient may experience tiredness, exhaustion and gastric disagreements as a result of the drug administration. Therefore, this form of therapy is strictly recorded under medical supervision. As a patient, it is important to adhere to a diet that is as low in salt as possible in order to limit further complications.

When should you go to the doctor?

Amyloidosis always requires medical treatment. If there are obvious signs of the disease, a doctor must be consulted quickly. They can then determine whether it is amyloidosis and initiate appropriate treatment.

Patients with chronic infections and inflammations such as arthritis or tuberculosis as well as patients on long-term dialysis and certain forms of bone marrow cancer (e.g. multiple myeloma) are particularly at risk and should speak to the responsible doctor immediately if amyloidosis is suspected.

This is especially true for older patients from the age of 40. If they notice increasing weakness and weight loss, a doctor’s visit is necessary. Since the organism is already weakened by the underlying disease, the amyloidosis must be treated immediately.

If there are any known cases of inherited amyloidosis in the family, medical advice is recommended at the first signs of illness. At the latest when skin changes such as bruises and swellings, cardiac arrhythmias and difficulty swallowing occur, a doctor must be consulted about amyloidosis.

Treatment & Therapy

Amyloidosis can only be treated to a limited extent. For the treatment of secondary diseases, however, there are some therapies available that can slow down the course.

If the heart is involved, a low-salt diet is recommended, as is the case if the kidneys are involved. Diuretics can also be given. Diuretics help the body flush out water and thus proteins.

The use of a pacemaker can be useful to counteract any cardiac arrhythmias ; dialysis is indicated if the kidney function is severely impaired to less than 15%.

Outlook & forecast

The further course of amyloidosis usually depends on the underlying disease and its treatment, so that a general course of the disease cannot be predicted in most cases.

As a rule, however, amyloidosis leads to severe discomfort in the heart, leading to cardiac insufficiency and disorders of the heart rhythm. This also significantly reduces the patient’s resilience and normal everyday activities or sports are no longer possible due to this disease. The quality of life is significantly reduced by this disease.

Similarly, it may also be the formation of a dementia are that significantly affects the everyday life of the patient. The patient may also be dependent on the help of other people in order to be able to continue to cope with everyday life. Renal insufficiency can also occur, so that the patient is dependent on a transplant or dialysis.

Direct treatment of amyloidosis is usually not possible. Most complaints can be limited and reduced through a special diet. However, the patient’s life expectancy may be reduced. In some cases a pacemaker can also be installed.


According to the current state of research, amyloidosis cannot be prevented. For familial amyloidosis, lifelong use of colchicine may delay an onset of amyloidosis. Sometimes chemotherapy with melphalan followed by blood stem cell therapy can delay amyloidosis.

If amyloidosis is suspected, if it can be assumed that the heart and kidneys will be affected, preventive care can be taken to maintain a low-salt diet.


In the case of amyloidoses, follow-up care depends on the type and severity of the disease and the patient’s individual symptoms. As a rule, long-term follow-up care with regular follow-up checks is necessary in the case of amyloidoses. Usually various organs as well as the endocrine system and soft tissue are affected.

A doctor must examine all of these areas and, if necessary, call in other specialists, as new symptoms can occasionally appear that require further diagnosis. Aftercare always includes regular adjustment of the medication. The patient usually has to take painkillers, anti-inflammatory drugs and other preparations that have to be adjusted to the current course of the disease at intervals of a few weeks to months.

If the outcome is positive, general measures such as the use of ACE inhibitors and diuretics can be gradually reduced. If the course is severe and involves the kidneys, dialysis treatment must be continued permanently. Regular follow-up checks are particularly necessary after chemotherapy, as is carried out in AL amyloidosis.

Due to the diverse manifestations of the disease, individual follow-up care can only be determined by a doctor. Those affected should consult the responsible doctor at an early stage so that the therapy concept can be effectively implemented.

You can do that yourself

Amyloidosis cannot yet be treated causally. The self-help measures focus on lifestyle changes and the use of alternative remedies. Basically, the medication must be optimally adjusted. The patient should note any side effects and interactions and inform the doctor about them. Unusual symptoms also need to be clarified before serious complications become noticeable.

If cardiac arrhythmias develop, the use of a pacemaker is indicated. Patients who experience noticeable symptoms are best advised to speak to the responsible doctor and have a comprehensive cardiological examination carried out. A proven natural remedy is green tea . The remedy prevents heart problems and also supports kidney function. At the same time, the patient must regularly take diuretics to help the body flush out fluids and thus proteins.

Alternatively, there is a homeopathic treatment. As part of the therapy, the homeopath works out the individually suitable remedies and prescribes them with regard to the current state of health of the person concerned. This allows the disease to be treated retrospectively by slowing down the disease process. A complete cure is unlikely with homeopathic treatment, but alternative therapy can have a positive effect on the course of the disease and alleviate the symptoms.